Products & Services
Advanced Structural Characterization of Antibody-Antigen Interactions Using HDX-MS and Molecular Modeling
Understand your antibody-antigen system at an unprecedented level of detail. Our integrated platform combines hydrogen-deuterium exchange mass spectrometry (HDX-MS) with molecular dynamics (MD) simulations to map conformational changes, binding interfaces, and dynamic interactions in solution. This service provides both quantitative insights and intuitive visualizations to support therapeutic development, epitope validation, or basic mechanistic studies.
- Requirements
- Customers must provide purified antibody and antigen in solution, with sufficient quantity to perform hydrogen-deuterium exchange mass spectrometry (HDX-MS) experiments. Protein samples should be stable and free from interfering additives such as glycerol or detergents.
- Expected Result
- The service delivers molecular dynamics simulation results integrated with HDX-MS data. Outputs include analyses of hydrogen bonding patterns, binding affinity estimates, conformational dynamics, and epitope mapping, offering molecular-level insights into antibody-antigen interaction mechanisms.
- Cost
- Pricing varies based on sample complexity and project scope. Please contact us directly for a tailored quote and timeline.
- Structural Visualization
- Interactive 3D models rendered in NGL Viewer, highlighting HDX-protected regions, conformational shifts, and binding interfaces for in-browser exploration.
- Hydrogen Bond Analysis
- Detailed visualization and quantification of hydrogen bonding networks at the antibody-antigen interface, including persistent bonds and transient interactions over simulation time.
- Structural Dynamics
- Side-by-side visualizations of structural dynamics pre- and post-binding, highlighting flexible regions, epitope hotspots, and conformational changes supported by HDX-MS and MD simulation data.
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